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Article

Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor.

American journal of physiology. Cell physiology - 1 Oct 2006

Kang Dawon, Han Jaehee, Kim Donghee

Abstract excerpt

TREK-2 is a member of the two-pore domain K(+) channel family and provides part of the background K(+) current in many types of cells. Neurotransmitters that act on receptors coupled to G(q) strongly inhibit TREK-2 and thus enhance cell excitability. The molecular basis for the inhibition of TREK-2 was studied. In COS-7 cells expressing TREK-2 and M(3) receptor, acetylcholine (ACh) applied to the bath solution...

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Source

Identifiers

PMID: 16672694
DOI: 10.1152/ajpcell.00047.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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