Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.

The Journal of biological chemistry - 26 Aug 2005

Murbartián Janet, Lei Qiubo, Sando Julianne J, Bayliss Douglas A

Abstract excerpt

Background potassium channels determine membrane potential and input resistance and serve as prominent effectors for modulatory regulation of cellular excitability. TREK-1 is a two-pore domain background K+ channel (KCNK2, K2P2.1) that is sensitive to a variety of physicochemical and humoral factors. In this work, we used a recombinant expression system to show that activation of G alpha(q)-coupled receptors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colforsin
Share to Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Maleimides

Share to Orexin Receptors

Share to Potassium

Share to Potassium Channels, Tandem Pore Domain

Share to Protein Kinase C

Share to Receptors, Neuropeptide

Source

Identifiers

PMID: 16006563
DOI: 10.1074/jbc.M503862200

Genes

KCNK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sequential phosphorylation mediates receptor- and kinase-induced inhibition of TREK-1 background potassium channels.PMID 16006563Read ↗

Properties of single two-pore domain TREK-2 channels expressed in mammalian cells.Semantic proximity Read ↗

17β-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor.Semantic proximity Read ↗

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.Semantic proximity Read ↗

Mechanism of inhibition of TREK-2 (K2P10.1) by the Gq-coupled M3 muscarinic receptor.Semantic proximity Read ↗

Functional Expression of TRESK-2, a New Member of the Tandem-pore K+ Channel FamilySemantic proximity Read ↗

Dominant negative effects of a non-conducting TREK1 splice variant expressed in brain.Semantic proximity Read ↗

Control of the single channel conductance of K2P10.1 (TREK-2) by the amino-terminus: role of alternative translation initiation.Semantic proximity Read ↗

Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormoneSemantic proximity Read ↗

C-terminal determinants of Kir4.2 channel expression.Semantic proximity Read ↗

Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK.Semantic proximity Read ↗

TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways.Semantic proximity Read ↗

Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.