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Article

Inhibition of human TREK-1 channels by caffeine and theophylline.

Epilepsy research - 1 May 2005

Harinath S, Sikdar S K

Abstract excerpt

Caffeine (1,3,7-trimethylxanthine) and theophylline (1,3-dimethylxanthine) are used for therapeutic purposes and can cause life-threatening convulsive seizures due to systemic toxicity. The mechanisms for the epileptogenicity of caffeine and theophylline are not clear. TWIK-related K(+) channels (TREK-1) are highly expressed in the human central nervous system and have a major role in the control of neuronal...

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Source

Identifiers

PMID: 15927451
DOI: 10.1016/j.eplepsyres.2005.03.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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