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Article

17β-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor.

The Journal of steroid biochemistry and molecular biology - 1 Oct 2018

Choudhury Nasreen, Sikdar Sujit Kumar

Abstract excerpt

TWIK-related potassium channel 1 (TREK1), a two-pore domain potassium channel, is modulated by various hormones and neurotransmitters by activation of membrane receptor - coupled second messengers. 17β-estradiol is a neuromodulator capable of regulating several cellular processes including the activity of ion channels, in a rapid and non-genomic manner. The G protein-coupled estrogen receptor (GPER) is known to...

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Source

Identifiers

PMID: 29883692
DOI: 10.1016/j.jsbmb.2018.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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