Article
In two genes, synergism of steroid hormone action is not mediated by cooperative binding of receptors to adjacent sites.
Molecular and cellular endocrinology - 1 Dec 1991
Bailly A, Rauch C, Cato A C, Milgrom E
Abstract excerpt
Synergistic action of multiple steroid hormone response elements (HREs) has been proposed to be due to cooperative binding of receptors. We have studied the cooperativity of steroid hormone receptor binding to synergistic HREs in two natural genes. In the mouse mammary tumor virus long terminal repeat that contains four progesterone receptor binding sites, no cooperativity in receptor binding was observed between...
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