Article
Selective synergy of immunoglobulin enhancer elements in B-cell development: a characteristic of kappa light chain enhancers, but not heavy chain enhancers.
Nucleic acids research - 11 Oct 1994
Fulton R, van Ness B
Abstract excerpt
We have examined the interactions of the enhancers of the kappa immunoglobulin light chain gene as well as the interactions of the intron, mu, and 3' alpha enhancers of the heavy chain locus in mouse. We have observed that each of the kappa enhancers is very weak in comparison with the heavy chai...
Topics
- Animals
- B-Lymphocytes
- Cell Line
- Enhancer Elements, Genetic
- Gene Deletion
- Immunoglobulin Heavy Chains
- Immunoglobulin kappa-Chains
- Introns
- Luciferases
- Macromolecular Substances
- Mice
- Mutation
- Plasmids
- Promoter Regions, Genetic
- Recombinant Fusion Proteins
- Transfection
- beta-Galactosidase