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Article

Steroid receptor transcriptional synergy is potentiated by disruption of the DNA-binding domain dimer interface.

Molecular endocrinology (Baltimore, Md.) - 1 Nov 1996

Liu W, Wang J, Yu G, Pearce D

Abstract excerpt

The dimer interface within the DNA-binding domain (DBD) of the steroid receptors stabilizes receptor binding to a palindromic DNA site termed a hormone response element (HRE) and is essential for receptor transcriptional activity when a single HRE drives transcription of a target gene. However, most steroid-responsive genes are driven by multiple HREs, and synergy between HREs is an important determinant of...

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PMID: 8923466
DOI: 10.1210/mend.10.11.8923466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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