Article
The adenovirus E1A protein is a potent coactivator for thyroid hormone receptors.
Molecular endocrinology (Baltimore, Md.) - 1 Jul 1999
Wahlström G M, Vennström B, Bolin M B
Abstract excerpt
The thyroid hormone receptors interact with several different cofactors when activating transciption. In this study, we show that the adenovirus E1A oncoprotein functions as a strong coactivator for the thyroid hormone receptor (TR), and that TR and E1A synergistically activate transcription via direct (DR4) or palindromic (IRO) hormone-responsive sites. Cotransfection experiments using different isoforms of the...
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