Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor.

doi:10.1016/0092-8674(90)90343-d

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor.

Cell - 23 Mar 1990

Fawell S E, Lees J A, White R, Parker M G

Abstract excerpt

We have identified a region within the steroid binding domain of the mouse estrogen receptor that is required for both receptor dimerization and high affinity DNA binding. Analysis of sequences in this region revealed that a heptad repeat of hydrophobic residues was conserved in all members of th...

Topics

Amino Acid Sequence
Animals
Antibodies
Base Sequence
Binding Sites
Chromosome Deletion
Ligands
Macromolecular Substances
Mice
Molecular Sequence Data
Mutation
Oligonucleotide Probes
Oligopeptides
Protein Biosynthesis
Receptors, Estrogen
Sequence Homology, Nucleic Acid
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 2317866
DOI: 10.1016/0092-8674(90)90343-d

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2317866-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics