Article
A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome.
Genome research - 1 May 2006
Ohno Mizuki, Miura Tomofumi, Furuichi Masato, Tominaga Yohei, Tsuchimoto Daisuke, Sakumi Kunihiko, Nakabeppu Yusaku
Abstract excerpt
8-Oxoguanine (8-oxoG), a major spontaneous form of oxidative DNA damage, is considered to be a natural cause of genomic diversity in organisms because of its mutagenic potential. The steady-state level of 8-oxoG in the nuclear genome of a human cell has been estimated to be several residues per 10(6) guanines. In the present study, to clarify the genome-wide distribution of 8-oxoG in the steady state, we...
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