Article
Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.
Progress in nucleic acid research and molecular biology - 1 Jan 2001
Hazra T K, Hill J W, Izumi T, Mitra S
Abstract excerpt
8-Oxoguanine (8-oxoG) is a critical mutagenic lesion because of its propensity to mispair with A during DNA replication. All organisms, from bacteria to mammals, express at least two types of 8-oxoguanine-DNA glycosylase (OGG) for repair of 8-oxoG. The major enzyme class (OGG1), first identified in Escherichia coli as MutM (Fpg), and later in yeast and humans, excises 8-oxoG when paired with C, T, and G but...
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