Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia.

The Journal of biological chemistry - 18 Jan 2013

Xia Tian, Lévy Laurence, Levillayer Florence, Jia Baosen, Li Gaiyun, Neuveut Christine, Buendia Marie-Annick, Lan Ke, Wei Yu

Abstract excerpt

Arkadia is a RING-based ubiquitin ligase that positively regulates TGF-β signaling by targeting several pathway components for ubiquitination and degradation. However, little is known about the mechanisms controlling Arkadia activity. Here we show that the LIM-only protein FHL2 binds and synergistically cooperates with Arkadia to activate Smad3/Smad4-dependent transcription. Knockdown of FHL2 by RNA interference...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Half-Life
Share to LIM-Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luciferases

Share to Muscle Proteins

Share to Transforming Growth Factor beta

Share to Ubiquitin

Share to Ubiquitin-Protein Ligases

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 23212909
DOI: 10.1074/jbc.M112.439760
PMCID: PMC3548488

Genes

FHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor β (TGF-β) signaling by regulating ubiquitination of the E3 ligase Arkadia.PMID 23212909Read ↗

How ubiquitination regulates the TGF‐β signalling pathway: New insights and new playersSemantic proximity Read ↗

Smurfs in Protein Homeostasis, Signaling, and CancerSemantic proximity Read ↗

Four and a half LIM domains protein 1 can be as a double-edged sword in cancer progression.Semantic proximity Read ↗

Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.Semantic proximity Read ↗

The Post-translational Modifications of Smurf2 in TGF-β SignalingSemantic proximity Read ↗

AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4.Semantic proximity Read ↗

The Role of UBE2-Conjugating Enzymes in the Mechanism of MuRF1 UbiquitylationSemantic proximity Read ↗

A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.Semantic proximity Read ↗

HECT and RING finger families of E3 ubiquitin ligases at a glanceSemantic proximity Read ↗

Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and ItchSemantic proximity Read ↗

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.Semantic proximity Read ↗

Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.