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Regulation of Hedgehog Signal Transduction by Ubiquitination and Deubiquitination

11 Dec 2021

Abstract excerpt

The Hedgehog (Hh) family of secreted proteins governs embryonic development and adult tissue homeostasis in species ranging from insects to mammals. Deregulation of Hh pathway activity has been implicated in a wide range of human disorders, including congenital diseases and cancer. Hh exerts its biological influence through a conserved signaling pathway. Binding of Hh to its receptor Patched (Ptc), a twelve-span...

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PMID: 34948134
DOI: 10.3390/ijms222413338

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