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Article

Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease.

Thyroid : official journal of the American Thyroid Association - 1 Apr 2006

Hodge Susan E, Ban Yoshiyuki, Strug Lisa J, Greenberg David A, Davies Terry F, Concepcion Erlinda S, Villanueva Ronald, Tomer Yaron

Abstract excerpt

Graves' disease (GD) is influenced by two major susceptibility loci, HLA-DR3 and thyroglobulin (Tg). Recently we have shown that specific HLA-DR and Tg gene sequences predispose to Graves' disease. Individuals carrying at least one arginine at position 74 of the DRbeta1 chain (denoted the R- genotype) have a significantly increased risk of GD, as do individuals homozygous for the single nucleotide protein (SNP)...

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Source

Identifiers

PMID: 16646680
DOI: 10.1089/thy.2006.16.351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Possible interaction between HLA-DRbeta1 and thyroglobulin variants in Graves' disease.PMID 16646680Read ↗

Arginine at position 74 of the HLA-DR beta1 chain is associated with Graves' disease.Semantic proximity Read ↗

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Dissecting the Genetic Susceptibility to Graves’ Disease in a Cohort of Patients of Italian OriginSemantic proximity Read ↗

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Association of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles with Graves' disease in a population representing the gene contribution from several ethnic backgrounds.Semantic proximity Read ↗

Single nucleotide polymorphisms at the PRR3, ABCF1, and GNL1 genes in the HLA class I region are associated with Graves' ophthalmopathy in a gender-dependent manner.Semantic proximity Read ↗

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