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Article

The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology.

Journal of autoimmunity - 1 Jan 2000

Jacobson Eric M, Huber Amanda, Tomer Yaron

Abstract excerpt

The autoimmune thyroid diseases (AITD) comprise a cadre of complex diseases whose underlying pathoetiology stems from a genetic-environmental interaction, between susceptibility genes (e.g. CTLA-4, HLA-DR, thyroglobulin) and environmental triggers (e.g. dietary iodine), that orchestrates the initiation of an autoimmune response to thyroid antigens, leading to the onset of disease. Abundant epidemiological data,...

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Source

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Identifiers

PMID: 18178059
DOI: 10.1016/j.jaut.2007.11.010
PMCID: PMC2244911

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Source receipt: pubmed, retrieved 7 Sept 2026.

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