Article
Myeloperoxidase gene variation as a determinant of atherosclerosis progression in the abdominal and thoracic aorta: an autopsy study.
Laboratory investigation; a journal of technical methods and pathology - 1 Jul 2003
Mäkelä Riikka, Karhunen Pekka J, Kunnas Tarja A, Ilveskoski Erkki, Kajander Olli A, Mikkelsson Jussi, Perola Markus, Penttilä Antti, Lehtimäki Terho
Abstract excerpt
Myeloperoxidase (MPO) is an enzyme that transforms low-density lipoprotein into atherogenic particles. The MPO gene has a promoter polymorphism at position -463, which affects gene transcription and leads to high- (G/G) and low-expression (A/A, A/G) genotypes. To determine if these genotypes are associated with the severity of atherosclerosis, we performed an autopsy study of 300 men aged 33 to 69 years (Helsinki...
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