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Article

Association of a myeloperoxidase promoter polymorphism with multiple sclerosis.

Journal of neuroimmunology - 26 Jun 2000

Kantarci O H, Atkinson E J, Hebrink D D, McMurray C T, Weinshenker B G

Abstract excerpt

Myeloperoxidase (MPO) generates hypochlorous acid and other reactive oxygen intermediates leading to tissue damage. MPO is expressed in macrophages-microglia in multiple sclerosis (MS) lesions. A G-->A substitution that abolishes an SP1 transcription factor consensus sequence in the promoter reduces gene expression. We studied the association of the genetic variant with MS. We did not find an association with...

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Share to MPO gene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 10742562
DOI: 10.1016/s0165-5728(00)00198-3

Genes

MPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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