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Article

CYP2D6 genotype and phenotype in Amerindians of Tepehuano origin and Mestizos of Durango, Mexico.

Journal of clinical pharmacology - 1 May 2006

Sosa-Macías Martha, Elizondo Guillermo, Flores-Pérez Carmen, Flores-Pérez Janet, Bradley-Alvarez Francisco, Alanis-Bañuelos Ruth E, Lares-Asseff Ismael

Abstract excerpt

Although the drug-metabolizing enzyme CYP2D6 has been studied extensively in subjects of differing ethnicities, limited CYP2D6 pharmacogenetic data are available for the Amerindian population and Mestizos of Mexico. Dextromethorphan hydroxylation phenotype was studied in Tepehuano Amerindian (n = 58) and Mestizo (n = 88) subjects, and 195 individuals (85 Tepehuano Amerindians and 110 Mestizos) were genotyped by...

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PMID: 16638736
DOI: 10.1177/0091270006287586

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