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Article

A comparative study of CYP3A4 polymorphisms in Mexican Amerindian and Mestizo populations.

Pharmacology - 1 Jan 2008

Reyes-Hernández Octavio D, Lares-Asseff Ismael, Sosa-Macias Martha, Vega Libia, Albores Arnulfo, Elizondo Guillermo

Abstract excerpt

Cytochrome P-450 3A4 (CYP3A4) contributes to the metabolism of approximately half the drugs in clinical use today. The aim of the present study was to determine the frequency of the CYP3A4*1B, *2, *4, *5, and *18 alleles amongst both Tepehuan Amerindians, a native group that has inhabited northern Mexico for thousands of years, and Mestizo Mexicans, and to compare the data with those of other populations....

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PMID: 17952011
DOI: 10.1159/000109983

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