Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design.

Annals of human genetics - 1 Nov 2002

Barratt B J, Payne F, Rance H E, Nutland S, Todd J A, Clayton D G

Abstract excerpt

Genotyping costs still preclude analysis of a comprehensive SNP map in thousands of individual subjects in the search for disease susceptibility loci. Allele frequency estimation in DNA pools from cases and controls offers a partial solution, but variance in these estimates will result in some loss of statistical power. However, there has been no systematic attempt to quantify the several sources of error in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosome Mapping

Share to Diabetes Mellitus, Type 1

Share to Gene Pool

Share to Genetic Markers

Share to Research Design

Share to Sample Size

Source

Identifiers

PMID: 12485472
DOI: 10.1017/S0003480002001252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design.PMID 12485472Read ↗

Impact and quantification of the sources of error in DNA pooling designs.Semantic proximity Read ↗

The impacts of errors in individual genotyping and DNA pooling on association studies.Semantic proximity Read ↗

Design of association studies with pooled or un-pooled next-generation sequencing data.Semantic proximity Read ↗

Most pooling variation in array-based DNA pooling is attributable to array error rather than pool construction error.Semantic proximity Read ↗

SNP allele frequency estimation in DNA pools and variance components analysis.Semantic proximity Read ↗

DNA Pooling: a tool for large-scale association studies.Semantic proximity Read ↗

SNP genotyping on pooled DNAs: comparison of genotyping technologies and a semi automated method for data storage and analysis.Semantic proximity Read ↗

Identification of disease causing loci using an array-based genotyping approach on pooled DNA.Semantic proximity Read ↗

Estimates of array and pool-construction variance for planning efficient DNA-pooling genome wide association studies.Semantic proximity Read ↗

A comparison of DNA pools constructed following whole genome amplification for two-stage SNP genotyping designs.Semantic proximity Read ↗

Streamlined analysis of pooled genotype data in SNP-based association studies.Semantic proximity Read ↗

Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arrays.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.