Article
Genome-wide association study for ovarian cancer susceptibility using pooled DNA.
Twin research and human genetics : the official journal of the International Society for Twin Studies - 1 Oct 2012
Lu Yi, Chen Xiaoqing, Beesley Jonathan, Johnatty Sharon E, deFazio Anna, Lambrechts Sandrina, Lambrechts Diether, Despierre Evelyn, Vergotes Ignace, Chang-Claude Jenny, Hein Rebecca, Nickels Stefan, Wang-Gohrke Shan, Dörk Thilo, Dürst Matthias, Antonenkova Natalia, Bogdanova Natalia, Goodman Marc T, Lurie Galina, Wilkens Lynne R, Carney Michael E, Butzow Ralf, Nevanlinna Heli, Heikkinen Tuomas, Leminen Arto, Kiemeney Lambertus A, Massuger Leon F A G, van Altena Anne M, Aben Katja K, Kjaer Susanne Krüger, Høgdall Estrid, Jensen Allan, Brooks-Wilson Angela, Le Nhu, Cook Linda, Earp Madalene, Kelemen Linda, Easton Douglas, Pharoah Paul, Song Honglin, Tyrer Jonathan, Ramus Susan, Menon Usha, Gentry-Maharaj Alexandra, Gayther Simon A, Bandera Elisa V, Olson Sara H, Orlow Irene, Rodriguez-Rodriguez Lorna, Macgregor Stuart, Chenevix-Trench Georgia
Abstract excerpt
Recent Genome-Wide Association Studies (GWAS) have identified four low-penetrance ovarian cancer susceptibility loci. We hypothesized that further moderate- or low-penetrance variants exist among the subset of single-nucleotide polymorphisms (SNPs) not well tagged by the genotyping arrays used in the previous studies, which would account for some of the remaining risk. We therefore conducted a time- and...
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