Article
Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides.
PloS one - 1 Jan 2012
Sugiyama Chisato, Yamamoto Michiyo, Kotani Tomomi, Kikkawa Fumitaka, Murata Yoshiharu, Hayashi Yoshitaka
Abstract excerpt
Proglucagon, which is encoded by the glucagon gene (Gcg), is the precursor of several peptide hormones, including glucagon and glucagon-like peptide 1 (GLP-1). Whereas glucagon stimulates hepatic glycogenolysis and gluconeogenesis, GLP-1 stimulates insulin secretion to lower blood glucose and also supports ß-cell proliferation and protection from apoptotic stimuli. Pregnancy is a strong inducer of change in islet...
Topics
- Animals
- Blood Glucose
- Cell Proliferation
- Cell Size
- Female
- Fertility
- Gene Knock-In Techniques
- Genotype
- Insulin
- Insulin-Secreting Cells
- Mice