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Article

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.

Developmental cell - 1 Jan 2002

Hu Yue, Ye Yihong, Fortini Mark E

Abstract excerpt

Nicastrin is genetically linked to Notch/lin-12 signaling in C. elegans and is part of a large multiprotein complex along with Presenilin. Here we describe the isolation and characterization of Drosophila Nicastrin (Nic) mutants. Nic mutants and tissue clones display characteristic Notch-like phenotypes. Genetic and inhibitor studies indicate a function for Nicastrin in the gamma-secretase step of Notch...

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Identifiers

PMID: 11782315
DOI: 10.1016/s1534-5807(01)00105-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.PMID 11782315Read ↗

Drosophila nicastrin is essential for the intramembranous cleavage of notch.Semantic proximity Read ↗

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Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.Semantic proximity Read ↗

Presenilin-based genetic screens in Drosophila melanogaster identify novel notch pathway modifiers.Semantic proximity Read ↗

Nicastrin binds to membrane-tethered Notch.Semantic proximity Read ↗

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.Semantic proximity Read ↗

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.Semantic proximity Read ↗

Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.Semantic proximity Read ↗

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.Semantic proximity Read ↗

The presenilins.Semantic proximity Read ↗

An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila BrainSemantic proximity Read ↗

Nicastrin controls aspects of photoreceptor neuron specification and differentiation in the Drosophila eye.Semantic proximity Read ↗

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