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Article

Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 3 Jun 2009

Tabuchi Katsuhiko, Chen Guiquan, Südhof Thomas C, Shen Jie

Abstract excerpt

Loss of presenilin function in adult mouse brains causes memory loss and age-related neurodegeneration. Since presenilin possesses gamma-secretase-dependent and -independent activities, it remains unknown which activity is required for presenilin-dependent memory formation and neuronal survival....

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Identifiers

PMID: 19494151
DOI: 10.1523/JNEUROSCI.1320-09.2009
PMCID: PMC2719251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19494151-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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