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Article

Nicastrin binds to membrane-tethered Notch.

Nature cell biology - 1 Aug 2001

Chen F, Yu G, Arawaka S, Nishimura M, Kawarai T, Yu H, Tandon A, Supala A, Song Y Q, Rogaeva E, Milman P, Sato C, Yu C, Janus C, Lee J, Song L, Zhang L, Fraser P E, St George-Hyslop P H

Abstract excerpt

The presenilins and nicastrin, a type 1 transmembrane glycoprotein, form high molecular weight complexes that are involved in cleaving the beta-amyloid precursor protein (betaAPP) and Notch in their transmembrane domains. The former process (termed gamma-secretase cleavage) generates amyloid beta-peptide (Abeta), which is involved in the pathogenesis of Alzheimer's disease. The latter process (termed S3-site...

Read the complete abstract on PubMed

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Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Aspartic Acid Endopeptidases

Share to Cell Membrane

Share to Endopeptidases

Share to Membrane Glycoproteins

Share to Receptors, Notch

Source

Identifiers

PMID: 11483961
DOI: 10.1038/35087069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nicastrin binds to membrane-tethered Notch.PMID 11483961Read ↗

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.Semantic proximity Read ↗

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.Semantic proximity Read ↗

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.Semantic proximity Read ↗

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.Semantic proximity Read ↗

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.Semantic proximity Read ↗

Drosophila nicastrin is essential for the intramembranous cleavage of notch.Semantic proximity Read ↗

gamma-cleavage-independent functions of presenilin, nicastrin, and Aph-1 regulate cell-junction organization and prevent tau toxicity in vivo.Semantic proximity Read ↗

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.Semantic proximity Read ↗

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.Semantic proximity Read ↗

Intramembrane proteolysis by gamma-secretase.Semantic proximity Read ↗

The presenilins.Semantic proximity Read ↗

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein.Semantic proximity Read ↗

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