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p53‐Dependent control of cell death by nicastrin: lack of requirement for presenilin‐dependent γ‐secretase complex

2 Feb 2009

Abstract excerpt

Nicastrin (NCT) is a component of the presenilin (PS)-dependent gamma-secretase complexes that liberate amyloid beta-peptides from the beta-Amyloid Precursor Protein. Several lines of evidence indicate that the members of these complexes could also contribute to the control of cell death. Here we show that over-expression of NCT increases the viability of human embryonic kidney (HEK293) cells and decreases...

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PMID: 19187441
DOI: 10.1111/j.1471-4159.2009.05952.x

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p53‐Dependent control of cell death by nicastrin: lack of requirement for presenilin‐dependent γ‐secretase complexPMID 19187441Read ↗

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