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Article

An Evolutionarily Conserved Role of Presenilin in Neuronal Protection in the Aging Drosophila Brain

12 May 2017

Abstract excerpt

Abstract Mutations in the Presenilin genes are the major genetic cause of Alzheimer’s disease. Presenilin and Nicastrin are essential components of γ-secretase, a multi-subunit protease that cleaves Type I transmembrane proteins. Genetic studies in mice previously demonstrated that conditional inactivation of Presenilin or Nicastrin in excitatory neurons of the postnatal forebrain results in memory deficits,...

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PMID: 28495961
DOI: 10.1534/genetics.116.196881

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