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Article

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion.

The Journal of biological chemistry - 16 Jun 2006

Griffin Erik E, Chan David C

Abstract excerpt

Mitofusins are conserved GTPases essential for the fusion of mitochondria. These mitochondrial outer membrane proteins contain a GTPase domain and two or three regions with hydrophobic heptad repeats, but little is known about how these domains interact to mediate mitochondrial fusion. To address this issue, we have analyzed the yeast mitofusin Fzo1p and find that mutation of any of the three heptad repeat...

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Identifiers

PMID: 16624808
DOI: 10.1074/jbc.M601847200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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