Article
A uvs-5 strain is deficient for a mitofusin gene homologue, fzo1, involved in maintenance of long life span in Neurospora crassa.
Eukaryotic cell - 1 Feb 2013
Kurashima Kiminori, Chae Michael, Inoue Hirokazu, Hatakeyama Shin, Tanaka Shuuitsu
Abstract excerpt
Mitochondria are highly dynamic organelles that continuously fuse and divide. To maintain mitochondria, cells establish an equilibrium of fusion and fission events, which are mediated by dynamin-like GTPases. We previously showed that an mus-10 strain, a mutagen-sensitive strain of the filamentous fungus Neurospora crassa, is defective in an F-box protein that is essential for the maintenance of mitochondrial DNA...
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