Article
The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission.
Molecular biology of the cell - 1 Sept 2001
Fukushima N H, Brisch E, Keegan B R, Bleazard W, Shaw J M
Abstract excerpt
Dnm1p belongs to a family of dynamin-related GTPases required to remodel different cellular membranes. In budding yeast, Dnm1p-containing complexes assemble on the cytoplasmic surface of the outer mitochondrial membrane at sites where mitochondrial tubules divide. Our previous genetic studies suggested that Dnm1p's GTPase activity was required for mitochondrial fission and that Dnm1p interacted with itself. In...
Topics
- Amino Acid Sequence
- Dynamin I
- Dynamins
- Escherichia coli
- Fungal Proteins
- GTP Phosphohydrolases
- Guanosine Triphosphate
- Hydrolysis
- Intracellular Membranes
- Kinetics
- Membrane Fusion
- Mitochondria
- Mitochondrial Proteins