Article
Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion.
The Journal of cell biology - 19 Feb 2001
Fritz S, Rapaport D, Klanner E, Neupert W, Westermann B
Abstract excerpt
Mitochondrial membrane fusion is a process essential for the maintenance of the structural integrity of the organelle. Since mitochondria are bounded by a double membrane, they face the challenge of fusing four membranes in a coordinated manner. We provide evidence that this is achieved by coupling of the mitochondrial outer and inner membranes by the mitochondrial fusion machinery. Fzo1, the first known mediator...
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