Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae.

The Journal of biological chemistry - 7 Aug 1998

Rapaport D, Brunner M, Neupert W, Westermann B

Abstract excerpt

Fzo1p is a novel component required for the biogenesis of functional mitochondria in the yeast Saccharomyces cerevisiae. The protein is homologous to Drosophila Fzo, the first known protein mediator of mitochondrial fusion. Deletion of the FZO1 gene results in a petite phenotype, loss of mitochondrial DNA, and a fragmented mitochondrial morphology. Fzo1p is an integral protein of the mitochondrial outer membrane...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fungal Proteins
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Fungal

Share to Membrane Proteins

Share to Mitochondria

Share to Phenotype

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Identifiers

PMID: 9685359
DOI: 10.1074/jbc.273.32.20150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae.PMID 9685359Read ↗

Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion.Semantic proximity Read ↗

Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion.Semantic proximity Read ↗

Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane.Semantic proximity Read ↗

Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.Semantic proximity Read ↗

When mitochondria fall apart: Unbalanced mitochondrial segregation triggers loss of mtDNA in the absence of mitochondrial fusionSemantic proximity Read ↗

Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion.Semantic proximity Read ↗

A uvs-5 strain is deficient for a mitofusin gene homologue, fzo1, involved in maintenance of long life span in Neurospora crassa.Semantic proximity Read ↗

An intermembrane space protein facilitates completion of mitochondrial division in yeastSemantic proximity Read ↗

Nonredundant roles of mitochondria-associated F-box proteins Mfb1 and Mdm30 in maintenance of mitochondrial morphology in yeast.Semantic proximity Read ↗

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion.Semantic proximity Read ↗

Genome-wide RNAi screen for regulators of UPR <sup>mt</sup> in <i>Caenorhabditis elegans</i> mutants with defects in mitochondrial fusionSemantic proximity Read ↗

Identification of a novel protein that regulates mitochondrial fusion by modulating mitofusin (Mfn) protein function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.