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Article

Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion.

Traffic (Copenhagen, Denmark) - 1 May 2007

Coonrod Emily M, Karren Mary Anne, Shaw Janet M

Abstract excerpt

The outer mitochondrial membrane protein Ugo1 forms a complex with the Fzo1p and Mgm1p GTPases that regulates mitochondrial fusion in yeast. Ugo1p contains two putative carrier domains (PCDs) found in mitochondrial carrier proteins (MCPs). Mitochondrial carrier proteins are multipass transmembrane proteins that actively transport molecules across the inner mitochondrial membrane. Mitochondrial carrier protein...

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Identifiers

PMID: 17451553
DOI: 10.1111/j.1600-0854.2007.00550.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Ugo1p is a multipass transmembrane protein with a single carrier domain required for mitochondrial fusion.PMID 17451553Read ↗

Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae.Semantic proximity Read ↗

Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion.Semantic proximity Read ↗

Charged flanking residues control the efficiency of membrane insertion of the first transmembrane segment in yeast mitochondrial Mgm1p.Semantic proximity Read ↗

Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane.Semantic proximity Read ↗

Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion.Semantic proximity Read ↗

Phospholipid association is essential for dynamin-related protein Mgm1 to function in mitochondrial membrane fusion.Semantic proximity Read ↗

Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion.Semantic proximity Read ↗

Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion.Semantic proximity Read ↗

The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission.Semantic proximity Read ↗

The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria.Semantic proximity Read ↗

Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.Semantic proximity Read ↗

Transportin1: a marker of FTLD-FUSSemantic proximity Read ↗

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