Article
OspE2 of Shigella sonnei is required for the maintenance of cell architecture of bacterium-infected cells.
Infection and immunity - 1 May 2006
Miura Masashi, Terajima Jun, Izumiya Hidemasa, Mitobe Jiro, Komano Teruya, Watanabe Haruo
Abstract excerpt
The OspE2 product of Shigella spp., the expression of which is regulated by the mxiE gene, is secreted through a type III secretion system into host cells. We investigated the function of OspE2 of Shigella sonnei by using cultured epithelial cells. Cells invaded by an ospE2 deletion mutant altered their morphology into the rounding shape, which was not due to cell death, whereas cells invaded by the wild-type...
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