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Article

IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells.

The EMBO journal - 15 Jun 1999

Tran Van Nhieu G, Caron E, Hall A, Sansonetti P J

Abstract excerpt

Shigella proteins that are targeted to host cells by a type III secretion apparatus are essential for reorganization of the cytoskeleton during cell invasion. We have developed a semi-permeabilized cell assay that tests the effects of bacterial proteins on the actin cytoskeleton. The Shigella IpaC protein was found to induce the formation of filopodial and lamellipodial extensions in these semi-permeabilized...

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Identifiers

PMID: 10369666
DOI: 10.1093/emboj/18.12.3249
PMCID: PMC1171406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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