Article
dksA is required for intercellular spread of Shigella flexneri via an RpoS-independent mechanism.
Infection and immunity - 1 Sept 2001
Mogull S A, Runyen-Janecky L J, Hong M, Payne S M
Abstract excerpt
Pathogenesis of Shigella flexneri is dependent on the ability of the bacterium to invade and spread within epithelial cells. In this study, we identified dksA as a gene necessary for intercellular spread in, but not invasion of, cultured cells. The S. flexneri dksA mutant exhibited sensitivity to acid and oxidative stress, in part due to an effect of DksA on production of RpoS. However, an S. flexneri rpoS mutant...
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