Article
Microtubule-severing activity of Shigella is pivotal for intercellular spreading.
Science (New York, N.Y.) - 10 Nov 2006
Yoshida Sei, Handa Yutaka, Suzuki Toshihiko, Ogawa Michinaga, Suzuki Masato, Tamai Asuka, Abe Akio, Katayama Eisaku, Sasakawa Chihiro
Abstract excerpt
Some pathogenic bacteria actually invade the cytoplasm of their target host cells. Invasive bacteria acquire the propulsive force to move by recruiting actin and inducing its polymerization. Here we show that Shigella movement within the cytoplasm was severely hindered by microtubules and that the bacteria destroyed surrounding microtubules by secreting VirA by means of the type III secretion system. Degradation...
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