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Article

Myosin IIA is essential for Shigella flexneri cell-to-cell spread.

Pathogens and disease - 1 Dec 2014

Lum Mabel, Morona Renato

Abstract excerpt

A key feature of Shigella pathogenesis is the ability to spread from cell-to-cell post-invasion. This is dependent on the bacteria's ability to initiate de novo F-actin tail polymerisation, followed by protrusion formation, uptake of bacteria-containing protrusion and finally, lysis of the double membrane vacuole in the adjacent cell. In epithelial cells, cytoskeletal tension is maintained by the actin-myosin II...

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Identifiers

PMID: 24989342
DOI: 10.1111/2049-632X.12202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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