IpaA targets beta1 integrins and rho to promote actin cytoskeleton rearrangements necessary for Shigella entry.

Abstract excerpt

Shigella invasion into the colonic epithelium involves many steps including the formation of large membrane protrusions by the epithelial cells that facilitate bacterial engulfment. IpaA, a Shigella protein secreted into target cells upon cell contact induces a loss of actin stress fibers in cells and promotes the reorganization of actin at the site of entry. The mechanism for this is not known but is thought to...

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