Article
Human CD4+CD25high regulatory T cells modulate myeloid but not plasmacytoid dendritic cells activation.
Journal of immunology (Baltimore, Md. : 1950) - 1 May 2006
Houot Roch, Perrot Ivan, Garcia Eric, Durand Isabelle, Lebecque Serge
Abstract excerpt
Human CD4(+)CD25(+) regulatory T cells (Treg) play an essential role in the prevention of autoimmune diseases. However, the mechanisms of immune suppression and the spectrum of cells they target in vivo remain incompletely defined. In particular, although Treg directly suppress conventional T cells in vitro, they have been shown to inhibit the Ag-presenting functions of macrophage- and monocyte-derived dendritic...
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