Article
TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2011
Nyirenda Mukanthu H, Sanvito Lara, Darlington Peter J, O'Brien Kate, Zhang Guang-Xian, Constantinescu Cris S, Bar-Or Amit, Gran Bruno
Abstract excerpt
Naturally occurring CD4(+)CD25(+)FOXP3(+) regulatory T cells suppress the activity of pathogenic T cells and prevent development of autoimmune responses. There is growing evidence that TLRs are involved in modulating regulatory T cell (Treg) functions both directly and indirectly. Specifically, TLR2 stimulation has been shown to reduce the suppressive function of Tregs by mechanisms that are incompletely...
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