Article
Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood.
Clinical & developmental immunology - 1 Jan 2008
Fujimaki Wakae, Takahashi Nozomu, Ohnuma Kei, Nagatsu Masayoshi, Kurosawa Hiromi, Yoshida Satoko, Dang Nam H, Uchiyama Takehiko, Morimoto Chikao
Abstract excerpt
CD25(+)CD4(+) regulatory T cells suppress T cell activation and regulate multiple immune reactions in in vitro and in vivo studies. To define the regulatory function of human CD25(+)CD4(+) T cells at various stages of maturity, we investigated in detail the functional differences of CD25(+)CD4(+) T cells from thymocytes, cord blood (CB), and adult peripheral blood (APB). CB CD25(+)CD4(+) T cells displayed...
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