Article
Frequency distribution of phenol sulfotransferase 1A1 activity in platelet cells from healthy Japanese subjects.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Jul 2006
Ohtake Eiko, Kakihara Fumiko, Matsumoto Naoko, Ozawa Shogo, Ohno Yasuo, Hasegawa Setsuo, Suzuki Hiroshi, Kubota Takahiro
Abstract excerpt
AIMS: To determine the distribution of sulfotransferase 1A1 (SULT1A1) activities, we used trans-4-hydroxytamoxifen (OHT) as a substrate to test samples from a Japanese population to examine whether the SULT1A1*2 allele can account for the wide distribution of OHT sulfating activity. We also studied genetic mutations other than the SULT1A1*2 allele to determine the cause of differences in SULT1A1 protein...
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