Article
A simple colorimetric assay for phenotyping the major human thermostable phenol sulfotransferase (SULT1A1) using platelet cytosols.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2000
Frame L T, Ozawa S, Nowell S A, Chou H C, DeLongchamp R R, Doerge D R, Lang N P, Kadlubar F F
Abstract excerpt
A thermostable phenol sulfotransferase, SULT1A1, has been implicated in numerous detoxification and bioactivation pathways; however, little is known regarding its endogenous function or its putative role in mediating risk for human environmental disease. A simple endpoint colorimetric assay is described that can be used for rapid phenotyping of SULT1A1 activity in human populations. The assay utilizes a...
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