A simple colorimetric assay for phenotyping the major human thermostable phenol sulfotransferase (SULT1A1) using platelet cytosols.

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Article

A simple colorimetric assay for phenotyping the major human thermostable phenol sulfotransferase (SULT1A1) using platelet cytosols.

Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2000

Frame L T, Ozawa S, Nowell S A, Chou H C, DeLongchamp R R, Doerge D R, Lang N P, Kadlubar F F

Abstract excerpt

A thermostable phenol sulfotransferase, SULT1A1, has been implicated in numerous detoxification and bioactivation pathways; however, little is known regarding its endogenous function or its putative role in mediating risk for human environmental disease. A simple endpoint colorimetric assay is described that can be used for rapid phenotyping of SULT1A1 activity in human populations. The assay utilizes a...

Topics

Adult
Aged
Blood Platelets
Colorimetry
Cytosol
Humans
Middle Aged
Naphthols
Phenotype
Substrate Specificity
Sulfotransferases

Source

Open in PubMed

Identifiers

PMID: 10950850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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