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Article

Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations.

The Biochemical journal - 1 Jan 1999

Coughtrie M W, Gilissen R A, Shek B, Strange R C, Fryer A A, Jones P W, Bamber D E

Abstract excerpt

Sulphation, catalysed by members of the sulphotransferase (SULT) enzyme family, is an important component of the body's chemical defence mechanism, but also acts to bioactivate mutagens such as hydroxylated aryl and heterocyclic amines. A major human sulphotransferase, SULT1A1 (P-PST), metabolizes and/or bioactivates many drugs, iodothyronines and hydroxylated aromatic amines. The enzyme activity varies widely...

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PMID: 9854023
PMCID: PMC1219934

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