Article
The Int-2/Fgf-3 oncogene product is secreted and associates with extracellular matrix: implications for cell transformation.
Molecular and cellular biology - 1 Dec 1991
Kiefer P, Peters G, Dickson C
Abstract excerpt
NIH3T3 cells transformed by mouse Int-2/Fgf-3 cDNA express a series of Int-2-related products representing discrete stages of processing and glycosylation. We confirm that in at least two highly transformed clonal lines, Int-2 products acquire further modifications and are efficiently secreted in...
Topics
- 3T3 Cells
- Animals
- Cell Transformation, Neoplastic
- Culture Media
- Extracellular Matrix
- Fibroblast Growth Factor 3
- Fibroblast Growth Factors
- Glycosaminoglycans
- Glycosylation
- Heparin
- Mice
- Phenotype
- Protein Processing, Post-Translational
- Proto-Oncogene Proteins