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Article

Influence of COMT gene polymorphism on fMRI-assessed sustained and transient activity during a working memory task.

Journal of cognitive neuroscience - 1 Jul 2010

de Frias Cindy M, Marklund Petter, Eriksson Elias, Larsson Anne, Oman Lena, Annerbrink Kristina, Bäckman Lars, Nilsson Lars-Göran, Nyberg Lars

Abstract excerpt

The catechol O-methyltransferase (COMT) gene--encoding an enzyme that is essential for the degradation of dopamine (DA) in prefrontal cortex (PFC)--contains a single nucleotide polymorphism (val/met) important for cognition. According to the tonic-phasic hypothesis, individuals carrying the low-e...

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Source

Identifiers

PMID: 19642882
DOI: 10.1162/jocn.2009.21318

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19642882-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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