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Article

Healthy aging increases the cognitive effects of two genes that influence extracellular dopamine.

Psychology and aging - 1 Jun 2014

Greenwood Pamela M, Lin Ming-Kuan, Sundararajan Ramya, Fryxell Karl J, Parasuraman Raja

Abstract excerpt

We hypothesized that normal variation in genes influencing the bioavailability of dopamine in prefrontal cortex contribute to inter-individual differences in working memory (WM), particularly in healthy old age. To test this, 858 healthy young, middle-aged, and older people were tested on a spatial WM task and genotyped for catechol-O-methyltransferase (COMT VAL158MET) and dopamine betahydroxylase (DBH; C-1021T)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24956005
DOI: 10.1037/a0036109

Genes

COMT
DBH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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