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Article

Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations.

Human mutation - 1 Jan 2010

Jorge-Nebert Lucia F, Jiang Zhengwen, Chakraborty Ranajit, Watson Joanna, Jin Li, McGarvey Stephen T, Deka Ranjan, Nebert Daniel W

Abstract excerpt

The human CYP1A1_CYP1A2 locus comprises the CYP1A1 (5,988 bp) and CYP1A2 (7,759 bp) transcribed regions, oriented head-to-head, sharing a bidirectional promoter of 23,306 bp. The older CYP1A1 gene appears more conserved and responsible for critical life function(s), whereas the younger CYP1A2 gene might have evolved more rapidly due to environmental (dietary) pressures. A population genetics study might confirm...

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PMID: 19802894
DOI: 10.1002/humu.21132
PMCID: PMC2797837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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