Article
Global patterns of variation in allele and haplotype frequencies and linkage disequilibrium across the CYP2E1 gene.
The pharmacogenomics journal - 1 Oct 2008
Lee M-Y, Mukherjee N, Pakstis A J, Khaliq S, Mohyuddin A, Mehdi S Q, Speed W C, Kidd J R, Kidd K K
Abstract excerpt
Cytochrome P450 2E1, gene symbol CYP2E1, is one of a family of enzymes with a central role in activating and detoxifying xenobiotics and endogenous compounds. Genetic variation at this gene has been reported in different human populations, and some association studies have reported increased risk for cancers and other diseases. To the best of our knowledge, multi-single-nucleotide polymorphism haplotypes and...
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